Activation of cardiac vagal afferents by oxygen-derived free radicals in rats.

Abstract

Myocardial ischemia and reperfusion can evoke excitation of cardiac vagal afferent nerve endings and activation of a cardiogenic depressor reflex (Bezold-Jarisch effect). We postulate that oxygen-derived free radicals, which are well known to be produced during prolonged ischemia and reperfusion, contribute to this excitation. Hydroxyl radicals derived from… (More)

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@article{Ustinova1994ActivationOC, title={Activation of cardiac vagal afferents by oxygen-derived free radicals in rats.}, author={Elena E. Ustinova and Harold D. Schultz}, journal={Circulation research}, year={1994}, volume={74 5}, pages={895-903} }