Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis.

@article{Silvestre1999ActivationOC,
  title={Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis.},
  author={J S Silvestre and Christophe Heymes and A Oub{\'e}na{\"i}ssa and V{\'e}ronique Robert and Brigitte Aupetit-Faisant and Alain Carayon and Bernard Swynghedauw and Claude Delcayre},
  journal={Circulation},
  year={1999},
  volume={99 20},
  pages={2694-701}
}
BACKGROUND This study analyzed the regulation and the role of the cardiac steroidogenic system in myocardial infarction (MI). METHODS AND RESULTS Seven days after MI, rats were randomized to untreated infarcted group or spironolactone- (20 and 80 mg x kg-1 x d-1), losartan- (8 mg x kg-1 x d-1), spironolactone plus losartan-, and L-NAME- (5 mg x kg-1 x d-1) treated infarcted groups for 25 days. Sham-operated rats served as controls. In the noninfarcted myocardium of the left ventricle (LV), MI… CONTINUE READING

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