Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice

@article{Silva2011ActivationOC,
  title={Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice},
  author={K. A. B. S. Silva and A. F. Paszcuk and G. F. Passos and E. S. Silva and J. Calixto},
  journal={PAIN®},
  year={2011},
  volume={152},
  pages={1872-1887}
}
Summary The pentacyclic triterpene α,β‐amyrin binds to CB1 and CB2 receptors and reduces inflammation and hyperalgesia in 2 models of persistent pain in mice. ABSTRACT In this study, we report that α,β‐amyrin, a plant‐derived pentacyclic triterpene, reduced persistent inflammatory and neuropathic hyperalgesia in mice by a direct activation of the CB1 and CB2 cannabinoid receptors (CB1R and CB2R). The oral treatment with α,β‐amyrin (30 mg/kg) significantly reduced mechanical and thermal… Expand
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