Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post‐ischemic pain model of complex regional pain syndrome type I in rats

@article{Xu2016ActivationOC,
  title={Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post‐ischemic pain model of complex regional pain syndrome type I in rats},
  author={Jijun Xu and Yuying Tang and Mian Xie and Bihua Bie and Jiang Wu and Hui Yang and Joseph F. Foss and Bin Yang and Richard Rosenquist and Mohamed Naguib},
  journal={European Journal of Neuroscience},
  year={2016},
  volume={44}
}
Complex regional pain syndrome type 1 (CRPS‐I) remains one of the most clinically challenging neuropathic pain syndromes and its mechanism has not been fully characterized. Cannabinoid receptor 2 (CB2) has emerged as a promising target for treating different neuropathic pain syndromes. In neuropathic pain models, activated microglia expressing CB2 receptors are seen in the spinal cord. Chemokine fractalkine receptor (CX3CR1) plays a substantial role in microglial activation and… 
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25 Citations

Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses
TLDR
This study provided putative novel targets that may help to develop effective therapeutics against CRPS-I and identified NLRP3 inflammasome in SCDH as a key contributor to the pain and inflammation responses in CPIP rats.
Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats
TLDR
In CCI- and ADPbetaS-treated rats, AM1241 pretreatment could efficiently activate CB2 receptor, while inhibiting p38MAPK and NF-kappaB activation in the dorsal spinal cord.
Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain
TLDR
This review will discuss the above-mentioned alternative approaches that show potential for treating neuropathic pain including NOP, including inhibition of degradation of a major endocannabinoid, 2-arachydonoylglycerol, which can attenuate NOP following trigeminal nerve injury in mice.
Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis.
Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model
Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment
TLDR
This work proposes focusing on the remission of abnormal bone turnover observed in CRPS using a recently developed concept: senso-immunology, and summarizes the history of TRPA1 and its involvement in pain sensation, inflammation, and CRPS.
N-methyl-d-aspartate receptor subunit 2B on keratinocyte mediates peripheral and central sensitization in chronic post-ischemic pain in male rats
Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats.
Role of Complement in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy
TLDR
The findings demonstrate a previously unknown but pivotal role of complement in CIPN and suggest that complement may be a new target for the development of novel therapeutics to manage this painful disease.
Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer
TLDR
It is demonstrated that bufalin relieves cancer-induced pain and bone destruction, which is mediated through the CB2 receptor, in the mouse bone cancer model.
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