Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post‐ischemic pain model of complex regional pain syndrome type I in rats

@article{Xu2016ActivationOC,
  title={Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post‐ischemic pain model of complex regional pain syndrome type I in rats},
  author={Jijun Xu and Yuying Tang and Mian Xie and Bihua Bie and Jiang Wu and Hui Yang and Joseph F. Foss and Bin Yang and Richard Rosenquist and Mohamed Naguib},
  journal={European Journal of Neuroscience},
  year={2016},
  volume={44}
}
Complex regional pain syndrome type 1 (CRPS‐I) remains one of the most clinically challenging neuropathic pain syndromes and its mechanism has not been fully characterized. Cannabinoid receptor 2 (CB2) has emerged as a promising target for treating different neuropathic pain syndromes. In neuropathic pain models, activated microglia expressing CB2 receptors are seen in the spinal cord. Chemokine fractalkine receptor (CX3CR1) plays a substantial role in microglial activation and… 
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References

SHOWING 1-10 OF 104 REFERENCES
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
TLDR
The prevention of microglial accumulation and activation in the dorsal spinal cord was associated with limited development of a neuropathic pain state and these results suggest that such interventions may also benefit humans with DPN, and their early introduction may also modify the development of the NeP state.
Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain
TLDR
The enhanced manifestations of neuropathic pain were replicated in irradiated wild-type mice reconstituted with bone marrow cells from CB2 knock-outs, thus demonstrating the implication of the CB2 receptor expressed in hematopoietic cells in the development of neuropathy pain at the spinal cord.
Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms
TLDR
Evaluating the involvement of inflammation, oxidative stress, and the transient receptor potential ankyrin 1 (TRPA1) channel, a chemosensor of inflammation and oxidative substances, in an animal model of chronic post-ischemia pain finds TRPA1 activation may be relevant for CRPS1/CPIP-induced acute and chronic pain.
Spinal Microglial and Perivascular Cell Cannabinoid Receptor Type 2 Activation Reduces Behavioral Hypersensitivity without Tolerance after Peripheral Nerve Injury
TLDR
These data indicate that intrathecal CBR2 agonists may provide analgesia by modulating the spinal immune response and microglial function in chronic pain conditions without inducing tolerance and neurologic side effects.
Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I).
...
...