Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury.

@article{Choi2013ActivationOC,
  title={Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury.},
  author={I Choi and Chung Ju and Angela M. A. Anthony Jalin and Da In Lee and Paul L. Prather and Won-Ki Kim},
  journal={The American journal of pathology},
  year={2013},
  volume={182 3},
  pages={928-39}
}
The type 2 cannabinoid receptor (CB2R) was recently shown to mediate neuroprotection in ischemic injury. However, the role of CB2Rs in the central nervous system, especially neuronal and glial CB2Rs in the cortex, remains unclear. We, therefore, investigated anti-ischemic mechanisms of cortical CB2R activation in various ischemic models. In rat cortical neurons/glia mixed cultures, a CB2R agonist, trans-caryophyllene (TC), decreased neuronal injury and mitochondrial depolarization caused by… CONTINUE READING