Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.

@article{Rahn2007ActivationOC,
  title={Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats.},
  author={Elizabeth J. Rahn and Alexandros Makriyannis and Andrea G Hohmann},
  journal={British journal of pharmacology},
  year={2007},
  volume={152 5},
  pages={765-77}
}
BACKGROUND AND PURPOSE The ability of cannabinoids to suppress mechanical hypersensitivity (mechanical allodynia) induced by treatment with the chemotherapeutic agent vincristine was evaluated in rats. Sites of action were subsequently identified. EXPERIMENTAL APPROACH Mechanical hypersensitivity developed over the course of ten daily injections of vincristine relative to groups receiving saline at the same times. Effects of the CB1/CB2 receptor agonist WIN55,212-2, the receptor-inactive… CONTINUE READING
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