Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line.

@article{Ishihara2000ActivationOC,
  title={Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line.},
  author={Ibuki Ishihara and Yasuhiro Minami and Tomoyuki Nishizaki and Takayuki Matsuoka and Hisako Yamamura},
  journal={Neuroscience letters},
  year={2000},
  volume={279 2},
  pages={97-100}
}
In order to reveal neurodegeneration elicited by reactive oxygen intermediates (ROI), neuronally differentiated cells from mouse embryonal carcinoma P19 cell line were exposed to hydrogen peroxide (H2O2). Enhanced protein-phosphorylation on tyrosine residues was detectable within 5 min of exposure to H2O2, and gradual rises in intracellular free Ca2+ level… CONTINUE READING