Activation of calcium currents in cardiac myocytes by empty beta-adrenoceptors.

  title={Activation of calcium currents in cardiac myocytes by empty beta-adrenoceptors.},
  author={Thorsten Mewes and S Dutz and Ursula Ravens and Karl Heinz Jakobs},
  volume={88 6},
BACKGROUND The cardiac calcium channel is known to be modulated by catecholamines via beta-adrenoceptors acting through intermediary GTP-binding regulatory proteins (G proteins). In biochemical studies on isolated membranes and reconstituted systems, it has been demonstrated that various G protein-coupled receptors, including beta-adrenoceptors, can activate G proteins and also intracellular second messengers like cyclic AMP (cAMP) even in the absence of an agonist and that antagonists can… CONTINUE READING


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