Activation of cPLA2 and sPLA2 in astrocytes exposed to simulated ischemia in vitro.

@article{Gabryel2007ActivationOC,
  title={Activation of cPLA2 and sPLA2 in astrocytes exposed to simulated ischemia in vitro.},
  author={Bożena Gabryel and Malgorzata Chalimoniuk and Anna Stolecka and J{\'o}zef Langfort},
  journal={Cell biology international},
  year={2007},
  volume={31 9},
  pages={958-65}
}
Both cytosolic PLA(2) (cPLA(2)) and secretory PLA(2) (sPLA(2)) have been implicated in pathology of cerebral ischemia. However, which of PLA(2) isoforms in astrocytes is responsible for arachidonic acid (AA) release contributing to their ischemic injury remains to be determined. The aim of the present study was to investigate the time-dependent activation of cPLA(2) and sPLA(2) in astrocytes exposed to combined oxygen glucose deprivation (OGD) as well as to evaluate the effectiveness of their… CONTINUE READING

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