Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.

@article{Chiang2014ActivationOC,
  title={Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice.},
  author={Yu-ting Alex Chiang and Wilfred Ip and Weijuan Shao and Zhuolun Eric Song and Jonathan Chernoff and Tianru Jin},
  journal={Endocrinology},
  year={2014},
  volume={155 6},
  pages={
          2122-32
        }
}
p21-activated protein kinase-1 (Pak1) plays a role in insulin secretion and glucagon-like peptide-1 (GLP-1) production. Pak1(-/-) mice were found to carry a defect in ip pyruvate tolerance test (IPPTT), leading us to speculate whether Pak1 represses hepatic gluconeogenesis. We show here that the defect in IPPTT became more severe in aged Pak1(-/-) mice. In primary hepatocytes, 2,2'-dihydroxy-1,1'-dinaphthyldisulfide, a potent inhibitor of group I Paks, reduced basal glucose production (GP… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations