Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation.

@article{Ao1998ActivationOC,
  title={Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation.},
  author={Yoko Ao and Hae Young Lopilly Park and Sylvia Olaizola-Horn and Barbara A. Gilchrest},
  journal={Experimental cell research},
  year={1998},
  volume={244 1},
  pages={117-24}
}
The cAMP-dependent pathway has been long presumed to play a critical role in mediating alpha-melanocyte-stimulating hormone (alpha-MSH)-induced pigmentation, but it has never been demonstrated that this pathway is obligatory. In order to determine whether the cAMP-dependent pathway is required for a alpha-MSH-induced pigmentation, we inhibited the activity of cAMP-dependent protein kinase (PKA), the main kinase mediating in this pathway, by introducing a physiologic cAMP-dependent protein… CONTINUE READING

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