Activation of cAMP–PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury

@article{Indolfi1997ActivationOC,
  title={Activation of cAMP–PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury},
  author={Ciro Indolfi and Enrico Vittorio Avvedimento and Emilio Di Lorenzo and Giovanni Esposito and Antonio Rapacciuolo and Paola Giuliano and Domenico Luca Grieco and Luigi Cavuto and Angela Maria Stingone and Ilaria Ciullo and Gianluigi Condorelli and Massimo Chiariello},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={775-779}
}
Injury of the arterial wall induces the formation of the neoin-tima1. This structure is generated by the growth of mitogenically activated smooth muscle cells of the arterial wall2–5. The molecular mechanism underlying the formation of the neointima involves deregulated cell growth, primarily triggered by the injury of the arterial wall6–9. The activated gene products transmitting the injury-induced mitogenic stimuli have been identified and inhibited by several means: transdominant negative… CONTINUE READING

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