Activation of c-erbB-2 and prognosis in ovarian carcinoma. Comparison with histologic type, grade, and stage.

@article{Singleton1994ActivationOC,
  title={Activation of c-erbB-2 and prognosis in ovarian carcinoma. Comparison with histologic type, grade, and stage.},
  author={Timothy Singleton and Tommasina Perrone and Giles Oakley and Gloria A. Niehans and Linda Carson and Steve S Cha and John G. Strickler},
  journal={Cancer},
  year={1994},
  volume={73 5},
  pages={1460-6}
}
BACKGROUND Prior reports suggested that measuring c-erbB-2 activation in ovarian carcinomas might be valuable in predicting prognosis. The authors attempted to confirm these studies while specifically excluding tumors of low malignant potential. METHODS The clinical and pathologic significance of c-erbB-2 oncogene activation was assessed in 56 ovarian carcinomas, none of which met histologic criteria for tumor of low malignant potential. RESULTS By using an immunohistochemical technique… CONTINUE READING

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