Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.

@article{Kranen1991ActivationOC,
  title={Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.},
  author={H. V. van Kranen and E. Vermeulen and L. Schoren and J. Bax and R. Woutersen and P. V. van Iersel and C. V. van Kreijl and E. Scherer},
  journal={Carcinogenesis},
  year={1991},
  volume={12 8},
  pages={
          1477-82
        }
}
  • H. V. van Kranen, E. Vermeulen, +5 authors E. Scherer
  • Published 1991
  • Biology, Medicine
  • Carcinogenesis
  • We have investigated the presence of mutations in ras genes at codons 12, 13 and 61 in chemically induced pancreatic tumors of rats and Syrian hamsters. Mutations were detected by means of allele-specific oligonucleotide hybridization to ras sequences amplified in vitro by the polymerase chain reaction. No mutations were observed in the c-K-ras gene or the c-H-ras gene of nine azaserine-induced adenomas and 15 carcinomas of the rat pancreas. This indicates that activated ras genes are not… CONTINUE READING
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