Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras.

  title={Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras.},
  author={V. Adler and Matthew R. Pincus and A. V. Polotskaya and Ximena Montano and Fred K. Friedman and Ze'ev A Ronai},
  journal={The Journal of biological chemistry},
  volume={271 38},
We have demonstrated previously that Jun-NH2-kinase (JNK) activation in vitro is potentiated by association with the p21(ras) protein. To determine if in vivo activation of JNK also depends on p21(ras), we have used M1311 cells that carry the cDNA for the neutralizing antibody to p21(ras), Y13-259, under a dexamethasone-inducible promoter. The ability of UV to activate JNK gradually decreased over a 4-day period of cell growth in dexamethasone. This decrease coincides with weaker… CONTINUE READING


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