Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor.

@article{Liu2011ActivationOC,
  title={Activation of c-Jun NH(2)-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor.},
  author={Hui Liu and Yunshan Liu and Manjula Viggeswarapu and Zhaomin Zheng and Louisa Titus and Scott D. Boden},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2011},
  volume={26 5},
  pages={1122-32}
}
Bone morphogenetic protein 2 (BMP-2) plays a critical role in the differentiation of precursor cells and has been approved for clinical application to induce new bone formation. To date, unexpectedly high doses of recombinant BMP-2 have been required to induce bone healing in humans. Thus, enhancing cellular responsiveness to BMP-2 potentially has critically important clinical implications. BMP responsiveness may be modulated in part by cross-talk with other signaling pathways, including… CONTINUE READING