Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2.

@article{Park1997ActivationOC,
  title={Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2.},
  author={Joo-Ho Park and Issac Kim and Young Joo Oh and Kok-onn Lee and Pyung Lim Han and Eui Jung Choi},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 27},
  pages={
          16725-8
        }
}
  • Joo-Ho Park, Issac Kim, +3 authors Eui Jung Choi
  • Published in
    The Journal of biological…
    1997
  • Biology, Medicine
  • Bcl-2 is an intracellular membrane-associated protein that prevents cell death induced by a variety of apoptotic stimuli. A mechanism by which Bcl-2 exerts an anti-cell death effect is, however, not fully understood. In the present study, Bcl-2 suppressed cell death of N18TG neuroglioma cells caused by various apoptotic stresses, including etoposide, staurosporine, anisomycin, and ultraviolet irradiation. Concomitantly, Bcl-2 disrupted a signaling cascade to the c-Jun N-terminal kinase… CONTINUE READING

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