Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells.

@article{Park2000ActivationOC,
  title={Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells.},
  author={Raekil Park and M. S. Kim and Hong-Seob So and Byung Hak Jung and Sun Rock Moon and S. Y. Chung and C B Ko and B. R. Kim and H. T. Chung},
  journal={Biochemical pharmacology},
  year={2000},
  volume={60 11},
  pages={
          1685-91
        }
}
Extracts of mistletoe (Viscum album var. coloratum) have been used for several decades as an anticancer immunomodulating agent in clinical fields. However, the mechanism by which the plant extracts kill tumor cells has remained elusive. We investigated the direct effects of beta-galactoside- and N-acetyl-d-galactosamine-specific mistletoe lectin II in inducing apoptotic death of U937 cells. Three distinct components of mistletoe, including beta-galactoside- and N-acetyl-D-galactosamine-specific… Expand
Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells.
TLDR
The evidence is provided that Korean mistletoe lectin-II induces apoptotic death of U937 cells via activation of caspase cascades, which is consistent with catalytic activation of protease. Expand
GAMMA-INTERFERON (IFN-γ) AUGMENTS APOPTOTIC RESPONSE TO MISTLETOE LECTIN-II VIA UPREGULATION OF FAS/FAS L EXPRESSION AND CASPASE ACTIVATION IN HUMAN MYELOID U937 CELLS
  • Myung-Sunny Kim, Jienny Lee, +9 authors R. Park
  • Biology, Medicine
  • Immunopharmacology and immunotoxicology
  • 2001
TLDR
The results suggest that the IFN-γ-differentiation of U937 cells increases the susceptibility to mistletoe lectin-II-induced apoptosis. Expand
Involvement of hydrogen peroxide in mistletoe lectin-II-induced apoptosis of myeloleukemic U937 cells.
TLDR
The results suggest that Korean mistletoe lectin-II is a strong inducer of pro-oxidant generation such as H2O2, which mediates the JNK/SAPK activation, cytochrome c release, activation of caspase-9 and caspases 3-like protease, and PARP cleavage in human myeloleukemic U937 cells. Expand
Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe.
TLDR
It is suggested that ERK1/2 and p38 MAPK may have opposite effects on cell survival in response to cytotoxic mistletoe lectin-II, which may contribute to the modulation of lect in-II-mediated cytot toxic activity. Expand
Critical Role of Reactive Oxygen Species and Mitochondrial Membrane Potential in Korean Mistletoe Lectin-Induced Apoptosis in Human Hepatocarcinoma Cells
TLDR
It is shown that VCA induces apoptosis by inducing ROS production and a loss of Δψm, in which JNK phosphorylation plays a critical role in these events, and that JNKosphorylation may be a major regulator involved in VCA-induced apoptosis. Expand
The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid Leukemia Cell Line.
TLDR
The results suggest that UDA may have therapeutic value for leukemia and would be studied further as a new drug for AML later on. Expand
Apoptosis Induction by Lectin Isolated from the Mushroom Boletopsis leucomelas in U937 Cells
TLDR
The Kurokawa lectin is the first mushroom lectin with apoptosis-inducing activity and was observed to induced apoptotic bodies formation, chromatin condensation, and DNA ladder formation, features of apoptosis. Expand
Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells
TLDR
Findings indicate an antileukemic effect for CvL and suggest that cathepsin B acts as a death mediator in C vL-induced cytotoxicity possibly in an uncharacterized connection with the membrane death receptor pathway. Expand
Apoptosis of K562 leukemia cells by Abnobaviscum F®, a European mistletoe extract.
TLDR
Results show that Abnobaviscum F induces apoptosis of K562 cells through the activation of the intrinsic caspase pathway, the phosphorylation of JNK-1, the reduction of cellular GSH, and the induction of ER stress. Expand
Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin (KML-B), a novel TLR4 agonist.
TLDR
In the present study, KML-B was found to be non-cytotoxic to bone marrow-derived dendritic cells (BMDCs) and the expressions of co-stimulatory molecules and the secretions of cytokines were increased in BMDCs by K ML-B. Expand
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