Activation of brain somatostatin 2 receptors stimulates feeding in mice: Analysis of food intake microstructure

@article{Stengel2010ActivationOB,
  title={Activation of brain somatostatin 2 receptors stimulates feeding in mice: Analysis of food intake microstructure},
  author={Andreas Stengel and Miriam Goebel and Lixin Wang and Jean Marc Rivier and Yvette Tach{\'e}},
  journal={Physiology & Behavior},
  year={2010},
  volume={101},
  pages={614-622}
}
We recently reported that the oligosomatostatin receptor agonist, ODT8-SST increases food intake in rats via the somatostatin 2 receptor (sst(2)). We characterized ingestive behavior following intracerebroventricular (icv) injection of a selective sst(2) agonist in freely fed mice during the light phase. The sst(2) agonist (0.01, 0.03, 0.1, 0.3 or 1μg/mouse) injected icv under short inhalation anesthesia dose-dependently increased cumulative light phase food intake over 4h compared to vehicle… CONTINUE READING

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