Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.

@article{Hall2012ActivationOB,
  title={Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation.},
  author={Belinda Suzette Hall and Shane R. Wilkinson},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 1},
  pages={115-23}
}
Benznidazole, a 2-nitroimidazole, is the front-line treatment used against American trypanosomiasis, a parasitic infection caused by Trypanosoma cruzi. Despite nearly 40 years of use, the trypanocidal activity of this prodrug is not fully understood. It has been proposed that benznidazole activation leads to the formation of reductive metabolites that can cause a series of deleterious effects, including DNA damage and thiol depletion. Here, we show that the key step in benznidazole activation… CONTINUE READING

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4,5-Dihydro-4,5-dihydroxyimidazoles as products of the reduction of 2-nitroimidazoles. HPLC assay and demonstration of equilibrium transfer of glyoxal to guanine

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