Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase.

@article{Kita2002ActivationOB,
  title={Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase.},
  author={Katsuhiro Kita and Noriyuki Sueyoshi and Nozomu Okino and Masanori Inagaki and Hideharu Ishida and Makoto Kiso and Shuhei Imayama and Takashi Nakamura and Makoto Ito},
  journal={The Biochemical journal},
  year={2002},
  volume={362 Pt 3},
  pages={
          619-26
        }
}
We have reported previously that the ceramidase from Pseudomonas aeruginosa AN17 isolated from a patient with atopic dermatitis requires detergents for hydrolysis of ceramide (Cer) [Okino, Tani, Imayama and Ito (1998) J. Biol. Chem. 273, 14368--14373]. In the present study, we report that some glycerophospholipids strongly activated the hydrolysis of Cer by Pseudomonas ceramidase in the absence of detergents. Among the glycerophospholipids tested, cardiolipin was most effective in stimulating… CONTINUE READING

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