Activation of autophagy is involved in the protective effect of 17β‐oestradiol on endotoxaemia‐induced multiple organ dysfunction in ovariectomized rats

Abstract

Oestrogens have been reported to attenuate acute inflammation in sepsis. In this study, the effects of long-term oestrogen replacement with 17β-oestradiol (E2 ) on endotoxaemia-induced circulatory dysfunction and multiple organ dysfunction syndrome were evaluated in ovariectomized (Ovx) rats. E2 (50 μg/kg, s.c., 3 times/week) was administered for 8 weeks… (More)
DOI: 10.1111/jcmm.13280

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@inproceedings{Chung2017ActivationOA, title={Activation of autophagy is involved in the protective effect of 17β‐oestradiol on endotoxaemia‐induced multiple organ dysfunction in ovariectomized rats}, author={Ming-Tzeung Chung and Yen-Mei Lee and Hsin-Hsueh Shen and Pao-Yun Cheng and Yu-chen Huang and Yu-Ju Lin and Yu-Yang Huang and Kwok-Keung Lam}, booktitle={Journal of cellular and molecular medicine}, year={2017} }