Activation of autophagy during cell death requires the engulfment receptor Draper

@inproceedings{McPhee2010ActivationOA,
  title={Activation of autophagy during cell death requires the engulfment receptor Draper},
  author={Christina K. McPhee and Mary A Logan and Marc R. Freeman and Eric H. Baehrecke},
  booktitle={Nature},
  year={2010}
}
Autophagy degrades cytoplasmic components that are required for cell survival in response to starvation. Autophagy has also been associated with cell death, but it is unclear how this is distinguished from autophagy during cell survival. Drosophila salivary glands undergo programmed cell death that requires autophagy genes, and engulfment of salivary gland cells by phagocytes does not appear to occur. Here we show that Draper (Drpr), the Drosophila melanogaster orthologue of the Caenorhabditis… CONTINUE READING

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