Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion.

@article{Ao2012ActivationOA,
  title={Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion.},
  author={Junping Ao and Jiao Jing Meng and Lei Zhu and Huizhen Nie and Chenchen Yang and Jinjun Li and Jianren Gu and Qiushi Lin and Weiwen Long and Xiaoqun Dong and Chao Li},
  journal={Molecular oncology},
  year={2012},
  volume={6 5},
  pages={
          507-15
        }
}
Androgen receptor (AR) activity is associated with cancer development and progression. In hepatocellular carcinoma (HCC), AR contributes to HCC incidence, but the role of AR in HCC cell migration and invasion remains largely unknown. In this study, we found that AR was expressed at high levels in a subgroup of HCC cell lines with high metastatic potential. Experiments using lentiviral overexpression or small hairpin RNA knockdown of AR as well as activation of AR by its ligand indicated that AR… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Foxa 1 and foxa 2 are essential for sexual dimorphism in

  • Z. Li, G. Tuteja
  • liver cancer
  • 2012

Novel insights on imaging sexhormonedependent tumourigenesis in vivo

  • B. Ramachandran, A. Stell
  • Endocr . Relat . Cancer
  • 2011

Essential phosphatases and a phosphodegron are critical for regulation of SRC3 / AIB 1 coactivator function and turnover

  • C. Li, Y. Y. Liang
  • Mol . Cell
  • 2008

Similar Papers

Loading similar papers…