Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats.

@article{Mioni2005ActivationOA,
  title={Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats.},
  author={Chiara Mioni and Carla Bazzani and Daniela Giuliani and Domenica Altavilla and Sheila Leone and Anna Ferrari and Letteria Minutoli and Alessandra Bitto and Herbert Marini and Davide Zaffe and Annibale R. Botticelli and A Iannone and Aldo Tomasi and Albertino Bigiani and Alfio Bertolini and Francesco Squadrito and Salvatore Guarini},
  journal={Critical care medicine},
  year={2005},
  volume={33 11},
  pages={2621-8}
}
OBJECTIVE A vagus nerve-mediated, brain cholinergic protective mechanism activated by melanocortin peptides is operative in conditions of circulatory shock; moreover, there is anatomical evidence of dual vagal-cardiac efferent pathways in rats, which could play different roles in controlling heart function. Therefore, we investigated the role and functional mechanism of such vagal efferent pathway(s) in an experimental model of ischemic heart disease. DESIGN Randomized experimental study… CONTINUE READING