Activation of an alkyl C-H bond geminal to an agostic interaction: an unusual mode of base-induced C-H activation.

@article{Hller2009ActivationOA,
  title={Activation of an alkyl C-H bond geminal to an agostic interaction: an unusual mode of base-induced C-H activation.},
  author={L Jonas L H{\"a}ller and Michael J. Page and Stuart A Macgregor and Mary F. Mahon and Michael K Whittlesey},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 13},
  pages={4604-5}
}
Deuterium labeling studies indicate that base-induced intramolecular C-H activation in the agostic complex 2-D proceeds with exclusive removal of a proton from the methyl arm of an (i)Pr substituent on the N-heterocyclic carbene (NHC) ligand. Computational studies show that this alkyl C-H bond activation reaction involves deprotonation of one of the C-H… CONTINUE READING