Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesis

@inproceedings{Rasmussen2009ActivationOA,
  title={Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesis},
  author={Mads Kristoffer Heilskov Rasmussen and Bruce Xiao Wang and Matthias R. Wabl and Anders Lade Nielsen and Finn Skou Pedersen},
  booktitle={Nucleic acids research},
  year={2009}
}
Retroviral insertional mutagenesis has been instrumental for the identification of genes important in cancer development. The molecular mechanisms involved in retroviral-mediated activation of proto-oncogenes influence the distribution of insertions within specific regions during tumorigenesis and hence may point to novel gene structures. From a retroviral tagging screen on tumors of 1767 SL3-3 MLV-infected BALB/c mice, intron 2 of the AP-1 repressor Jdp2 locus was found frequently targeted by… CONTINUE READING

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