Corpus ID: 20127684

Activation of alpha 2-adrenergic receptors decreases Ca2+ influx to inhibit insulin secretion in a hamster beta-cell line: an action mediated by a guanosine triphosphate-binding protein.

@article{Hsu1991ActivationOA,
  title={Activation of alpha 2-adrenergic receptors decreases Ca2+ influx to inhibit insulin secretion in a hamster beta-cell line: an action mediated by a guanosine triphosphate-binding protein.},
  author={W. H. Hsu and H. Xiang and A. S. Rajan and A. E. Boyd},
  journal={Endocrinology},
  year={1991},
  volume={128 2},
  pages={
          958-64
        }
}

W. H. Hsu, H. Xiang, +1 author A. E. Boyd

Published 1991

Medicine

Endocrinology

Activation of the sympathetic nervous system inhibits insulin secretion. We tested the hypothesis that activation of alpha 2-adrenergic receptors on the beta-cell by epinephrine or clonidine attenuates insulin release by an effect on the voltage-dependent Ca2+ channel (VDCC) and examined the role of G-proteins in this signal transduction pathway. Using a cultured SV40-transformed hamster beta-cell line (HIT cells) as a model system, we determined the effect of alpha 2-adrenergic agonists on… CONTINUE READING

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