Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts

@article{Ha1993ActivationOA,
  title={Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts},
  author={Kwon Soo Ha and John H. Exton},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={123},
  pages={1789 - 1796}
}
alpha-Thrombin induced a change in the cell morphology of IIC9 fibroblasts from a semiround to an elongated form, accompanied by an increase in stress fibers. Incubation of the cells with phospholipase D (PLD) from Streptomyces chromofuscus and exogenous phosphatidic acid (PA) caused similar morphological changes, whereas platelet-derived growth factor (PDGF) and phorbol 12-myristate 13-acetate (PMA) induced different changes, e.g., disruption of stress fibers and cell rounding. alpha-Thrombin… CONTINUE READING

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