Activation of aconitase in mouse fast-twitch skeletal muscle during contraction-mediated oxidative stress.


Aconitase is a mitochondrial enzyme that converts citrate to isocitrate in the tricarboxylic acid cycle and is inactivated by reactive oxygen species (ROS). We investigated the effect of exercise/contraction, which is associated with elevated ROS production, on aconitase activity in skeletal muscle. Humans cycled at 75% of maximal workload, followed by six… (More)


7 Figures and Tables

Slides referencing similar topics