Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling

  title={Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling},
  author={W. Zeng and Di-Shi Liu and L. Liu and Liang She and L. Wu and T. Xu},
  journal={Scientific Reports},
  • W. Zeng, Di-Shi Liu, +3 authors T. Xu
  • Published 2015
  • Chemistry, Medicine
  • Scientific Reports
  • Extracellular transients of pH alterations likely mediate signal transduction in the nervous system. Neuronal acid-sensing ion channels (ASICs) act as sensors for extracellular protons, but the mechanism underlying ASIC activation remains largely unknown. Here, we show that, following activation of a light-activated proton pump, Archaerhodopsin-3 (Arch), proton transients induced ASIC currents in both neurons and HEK293T cells co-expressing ASIC1a channels. Using chimera proteins that bridge… CONTINUE READING
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