Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling

@inproceedings{Zeng2015ActivationOA,
  title={Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling},
  author={Wei-Zheng Zeng and Di-Shi Liu and Lili Liu and Liang She and Long-Jun Wu and Tian-Le Xu},
  booktitle={Scientific reports},
  year={2015}
}
Extracellular transients of pH alterations likely mediate signal transduction in the nervous system. Neuronal acid-sensing ion channels (ASICs) act as sensors for extracellular protons, but the mechanism underlying ASIC activation remains largely unknown. Here, we show that, following activation of a light-activated proton pump, Archaerhodopsin-3 (Arch), proton transients induced ASIC currents in both neurons and HEK293T cells co-expressing ASIC1a channels. Using chimera proteins that bridge… CONTINUE READING
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