Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling

@article{Zeng2015ActivationOA,
  title={Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling},
  author={W. Zeng and Di-Shi Liu and L. Liu and Liang She and L. Wu and T. Xu},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
  • W. Zeng, Di-Shi Liu, +3 authors T. Xu
  • Published 2015
  • Chemistry, Medicine
  • Scientific Reports
  • Extracellular transients of pH alterations likely mediate signal transduction in the nervous system. Neuronal acid-sensing ion channels (ASICs) act as sensors for extracellular protons, but the mechanism underlying ASIC activation remains largely unknown. Here, we show that, following activation of a light-activated proton pump, Archaerhodopsin-3 (Arch), proton transients induced ASIC currents in both neurons and HEK293T cells co-expressing ASIC1a channels. Using chimera proteins that bridge… CONTINUE READING
    13 Citations

    Figures and Topics from this paper.

    Protons as Messengers of Intercellular Communication in the Nervous System
    • 8
    • Highly Influenced
    • PDF
    Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….
    • L. Rash
    • Biology, Medicine
    • Advances in pharmacology
    • 2017
    • 27
    Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy
    • 15
    Optogenetic approaches addressing extracellular modulation of neural excitability
    • 21
    • PDF
    Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection?
    • 2
    Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain123
    • 54
    • PDF

    References

    SHOWING 1-10 OF 73 REFERENCES
    Acid-sensing Ion Channels in Sensory Perception*
    • E. Lingueglia
    • Medicine, Biology
    • Journal of Biological Chemistry
    • 2007
    • 277
    • PDF
    A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
    • 149
    • PDF
    Characterization of Acid-sensing Ion Channels in Dorsal Horn Neurons of Rat Spinal Cord*
    • 151
    • PDF
    Receptor for protons: First observations on Acid Sensing Ion Channels
    • 23
    Coupling between NMDA Receptor and Acid-Sensing Ion Channel Contributes to Ischemic Neuronal Death
    • Jun Gao, Bo Duan, +4 authors T. Xu
    • Biology, Medicine
    • Neuron
    • 2005
    • 263
    • PDF
    Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels*
    • 385
    • PDF