Activation of a subset of genes by IFN-gamma requires IKKbeta but not interferon-dependent activation of NF-kappaB.

@article{Shultz2007ActivationOA,
  title={Activation of a subset of genes by IFN-gamma requires IKKbeta but not interferon-dependent activation of NF-kappaB.},
  author={David B Shultz and John D. Fuller and Yonghui Yang and Nywana S Sizemore and Mysore R Sandhya Rani and George R Stark},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2007},
  volume={27 10},
  pages={875-84}
}
Activation of NF-kappaB requires the inhibitor of kappaB (IkappaB) kinase (IKK) complex, which is made up of two functional kinases, IKKalpha and IKKbeta, and the scaffolding protein IKKgamma. We recently identified several interferon-gamma (IFN-gamma)-stimulated genes (ISGs) that are not induced in mouse embryonic fibroblast cells (MEFs) doubly null for the expression of IKKalpha and IKKbeta. We show here that the IFN-gamma-induced transcription of IKK-dependent ISGs requires IKKbeta but not… CONTINUE READING

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