Activation of a p44 pseudogene in Anaplasma phagocytophila by bacterial RNA splicing: a novel mechanism for post‐transcriptional regulation of a multigene family encoding immunodominant major outer membrane proteins

@article{Zhi2002ActivationOA,
  title={Activation of a p44 pseudogene in Anaplasma phagocytophila by bacterial RNA splicing: a novel mechanism for post‐transcriptional regulation of a multigene family encoding immunodominant major outer membrane proteins},
  author={N. Zhi and N. Ohashi and Y. Rikihisa},
  journal={Molecular Microbiology},
  year={2002},
  volume={46}
}
  • N. Zhi, N. Ohashi, Y. Rikihisa
  • Published 2002
  • Biology, Medicine
  • Molecular Microbiology
  • Immunodominant 44 kDa major outer membrane proteins of Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) are encoded by the p44 multigene family. One of the paralogues, p44–18 is predominantly expressed by A. phagocytophila in mammalian hosts, but is downregulated in the arthropod vector. The expression of p44–18 was upregulated in A. phagocytophila cultivated in HL‐60 cells at 37°C compared with 24°C. However, the molecular mechanism of such gene expression was unclear, as p44… CONTINUE READING
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