Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.

@article{Nick1996ActivationOA,
  title={Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.},
  author={J. M. Armstrong Nick and Natalie J. Avdi and P{\"a}r Gerwins and Gary Leon Johnson and George Scott Worthen},
  journal={Journal of immunology},
  year={1996},
  volume={156 12},
  pages={4867-75}
}
Stimulation of human neutrophils by LPS is central to the pathogenesis of sepsis and the adult respiratory distress syndrome. The intracellular signaling pathway that results in cellular responses following LPS stimulation in neutrophils is unknown. We report that exposure of neutrophils to LPS results in the phosphorylation and activation of a p38 mitogen… CONTINUE READING