Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.

@article{Jonkers1997ActivationOA,
  title={Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.},
  author={Jos Jonkers and Hendrik C. Korswagen and Dennis S Acton and Marco Breuer and Anton Berns},
  journal={The EMBO journal},
  year={1997},
  volume={16 3},
  pages={441-50}
}
Acceleration of lymphomagenesis in oncogene-bearing transgenic mice by slow-transforming retroviruses has proven a valuable tool in identifying cooperating oncogenes. We have modified this protocol to search for genes that can collaborate effectively with the transgene in later stages of tumor development. Propagation of tumors induced by Moloney murine leukemia virus (M-MuLV) in E mu-Pim1 or H2-K-myc transgenic mice by transplantation to syngeneic hosts permitted proviral tagging of… CONTINUE READING

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