Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

@article{Issemann1990ActivationOA,
  title={Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators},
  author={I. Issemann and S. Green},
  journal={Nature},
  year={1990},
  volume={347},
  pages={645-650}
}
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man. 
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