Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.

  title={Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.},
  author={X. H. Liu and T. Liu and Diane C Slusarski and Julia A. Yang-Snyder and Craig C. Malbon and Randall T. Moon and H. Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 25},
  • X. LiuT. Liu H. Wang
  • Published 7 December 1999
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
The frizzled gene family of putative Wnt receptors encodes proteins that have a seven-transmembrane-spanning motif characteristic of G protein-linked receptors, though no loss-of-function studies have demonstrated a requirement for G proteins for Frizzled signaling. We engineered a Frizzled-2 chimera responsive to beta-adrenergic agonist by using the ligand-binding domains of the beta(2)-adrenergic receptor. The expectation was that the chimera would be sensitive both to drug-mediated… 

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