Activation of a development-specific gene, dofA, by FruA, an essential transcription factor for development of Myxococcus xanthus.

Abstract

FruA is an essential transcription factor for Myxococcus xanthus development. The expression of tps and dofA genes is fruA dependent. In this study, we show by gel shift and footprint assays with the C-terminal DNA-binding domain of FruA and by a lacZ fusion assay that FruA may directly activate dofA expression during development. 

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