Activation of a cyclic nucleotide phosphodiesterase 4 (PDE4) from rat thymocytes by phosphatidic acid.

@article{Savany1996ActivationOA,
  title={Activation of a cyclic nucleotide phosphodiesterase 4 (PDE4) from rat thymocytes by phosphatidic acid.},
  author={Alain Savany and C Abriat and Georges M. N{\'e}moz and Michel Guichardant andMichel Lagarde and Annie France Prigent},
  journal={Cellular signalling},
  year={1996},
  volume={8 7},
  pages={
          511-6
        }
}
The cytosolic cyclic nucleotide phosphodiesterase (PDE) activity from rat thymocytes was resolved into five peaks by HPLC. Only two forms of the cAMP-specific PDE4 were found to be sensitive to physiologically relevant phosphatidic acid (PA) concentrations. PA activated the PDE4-peak 3 form, the fatty acid composition and unsaturation degree determining the efficiency of PA. The PDE4-peak 2 form was inhibited only by PA with saturated fatty acyl groups. PDE4 activation was specific of anionic… CONTINUE READING
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