Activation of a UBC4-dependent pathway of ubiquitin conjugation during postnatal development of the rat testis.

@article{Rajapurohitam1999ActivationOA,
  title={Activation of a UBC4-dependent pathway of ubiquitin conjugation during postnatal development of the rat testis.},
  author={Venkatesh Rajapurohitam and Carlos R. Morales and Mohamed El-Alfy and Stephane Lefrancois and Nathalie B{\'e}dard and Simon S Wing},
  journal={Developmental biology},
  year={1999},
  volume={212 1},
  pages={217-28}
}
During spermatogenesis, germ cells undergo mitotic and meiotic divisions to form haploid round spermatids which mature to functional elongated spermatozoa. During this process there occurs remodeling of cell structure and loss of most of the cytoplasm and a large fraction of cellular proteins. To evaluate the role of the ubiquitin proteolytic system in this protein loss, we measured levels of ubiquitinated proteins and rates of ubiquitin conjugation in extracts of testes from rats of different… CONTINUE READING

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