Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity.

@article{Kawano2010ActivationOA,
  title={Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity.},
  author={Yoji Kawano and Akira Akamatsu and Keiko Y Hayashi and Yusuke Housen and Jun Okuda and Ai Yao and Ayako Nakashima and Hiroki Takahashi and Hitoshi Yoshida and Hann Ling Wong and Tsutomu Kawasaki and Ko Shimamoto},
  journal={Cell host & microbe},
  year={2010},
  volume={7 5},
  pages={362-75}
}
The nucleotide-binding domain and leucine-rich repeat-containing (NLR) family proteins recognize pathogen-derived molecules and trigger immune responses in both plants and animals. In plants, the direct or indirect recognition of specific pathogen effectors by NLRs culminates in a hypersensitive response (HR) and the production of reactive oxygen species (ROS), key components of the plant defense response. However, the molecules activated by NLRs and how they induce immune responses are largely… CONTINUE READING

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