Activation of a Plasmodium falciparum protease correlated with merozoite maturation and erythrocyte invasion

  title={Activation of a Plasmodium falciparum protease correlated with merozoite maturation and erythrocyte invasion},
  author={Catherine Braun‐Breton and Luis Pereira da Silva},
  journal={Biology of the Cell},

Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase.

The proposed PfSUB2 belongs to a subclass of eukaryotic subtilisins different from proprotein convertases, a secretory organelle whose contents are believed to participate in a late step of the erythrocyte invasion.

Metalloprotease Activity in a Small Heat Shock Protein of the Human Malaria Parasite Plasmodium vivax

The characterization of a metalloprotease activity which resides in the small HSP (PVHSP28) of the common but noncultivable human malaria parasite Plasmodium vivax is described and it is indicated that this enzyme probably belongs to a new class of HSPs which possess the metalliprotease signature sequence.



Involvement of malarial proteases in the interaction between the parasite and host erythrocyte in Plasmodium knowlesi infections.

The results suggested that proteases of merozoites might play some crucial role in the invasion process of Plasmodium knowlesi merozosites.

The three major antigens on the surface of Plasmodium falciparum merozoites are derived from a single high molecular weight precursor

Three unique fragments of 83,000, 42,000 and 19,000 mol wt are present and they represent the major surface antigens of P. falciparum merozoites and are used to identify the terminal processing products associated with the merozosite.

Identification of three stage-specific proteinases of Plasmodium falciparum

Three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH are identified and the correlation between the effects of proteinase inhibitors on the isolated enzymes with the results suggest potential critical functions for these proteinases in the life cycle of malaria parasites.

Immunity to Asexual Erythrocytic Stages of Plasmodium Falciparum: Role of Defined Antigens in the Humoral Response 1

The pathological consequences of malaria, characterized by febrile paroxysms, anemia, splenomegaly and debilitation, are due to the development and proliferation of asexual erythrocytic stages in the vertebrate host.