Activation of a Meiotic Checkpoint during Drosophila Oogenesis Regulates the Translation of Gurken through Chk2/Mnk

Abstract

BACKGROUND During Drosophila oogenesis, unrepaired double-strand DNA breaks activate a mei-41-dependent meiotic checkpoint, which couples the progression through meiosis to specific developmental processes. This checkpoint affects the accumulation of Gurken protein, a transforming growth factor alpha-like signaling molecule, as well as the morphology of the… (More)
DOI: 10.1016/S0960-9822(02)01165-X

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