Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

  title={Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.},
  author={D. A. Harrison and R. Binari and T. Nahreini and M. Gilman and N. Perrimon},
  journal={The EMBO Journal},
  • D. A. Harrison, R. Binari, +2 authors N. Perrimon
  • Published 1995
  • Biology, Medicine
  • The EMBO Journal
  • In mammals, many cytokines and growth factors stimulate members of the Janus kinase (JAK) family to transduce signals for the proliferation and differentiation of various cell types, particularly in hematopoietic lineages. Mutations in the Drosophila hopscotch (hop) gene, which encodes a JAK, also cause proliferative defects. Loss‐of‐function alleles result in lethality and underproliferation of diploid tissues of the larva. A dominant gain‐of‐function allele, Tumorous‐lethal (hopTum‐l), leads… CONTINUE READING
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