Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

@article{Harrison1995ActivationOA,
  title={Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.},
  author={Douglas A. Harrison and Richard Binari and Theresa Stines Nahreini and Michael Gilman and Norbert Perrimon},
  journal={The EMBO Journal},
  year={1995},
  volume={14}
}
In mammals, many cytokines and growth factors stimulate members of the Janus kinase (JAK) family to transduce signals for the proliferation and differentiation of various cell types, particularly in hematopoietic lineages. Mutations in the Drosophila hopscotch (hop) gene, which encodes a JAK, also cause proliferative defects. Loss‐of‐function alleles result in lethality and underproliferation of diploid tissues of the larva. A dominant gain‐of‐function allele, Tumorous‐lethal (hopTum‐l), leads… 
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The results suggest that the Toll/Cactus signal transduction pathway plays a significant role in regulating hemocyte proliferation and hemocyte density in the Drosophila larva.
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