Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.

  title={Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.},
  author={Bryan A. Ballif and Lionel Arnaud and William T. Arthur and Deborah L. Guris and Akira Imamoto and Jonathan A Cooper},
  journal={Current Biology},
During brain development, many neurons migrate long distances before settling and differentiating. These migrations are coordinated to ensure normal development. The secreted protein Reelin controls the locations of many types of neurons, and its absence causes the classic "Reeler" phenotype. Reelin action requires tyrosine phosphorylation of the intracellular protein Dab1 by Src-family kinases. However, little is known about signaling pathways downstream of Dab1. Here, we identify several… CONTINUE READING

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