Activation of a Ca2+-permeable cation channel by two different inducers of apoptosis in a human prostatic cancer cell line.

@article{Gutierrez1999ActivationOA,
  title={Activation of a Ca2+-permeable cation channel by two different inducers of apoptosis in a human prostatic cancer cell line.},
  author={Andres A Gutierrez and Juan Manuel Arias and Lissette Garcia and Jaime Mas-Oliva and Agust{\'i}n Guerrero-Hern{\'a}ndez},
  journal={The Journal of physiology},
  year={1999},
  volume={517 ( Pt 1)},
  pages={95-107}
}
1. We have combined patch clamp recording with simultaneous [Ca2+]i measurements in single LNCaP cells (a human prostate cancer cell line), to study the activation of Ca2+-permeable channels by two different inducers of apoptosis, ionomycin and serum deprivation. 2. In perforated patch recording, LNCaP cells had a membrane potential of -40 mV and a resting [Ca2+]i of 90 nM. Application of ionomycin at levels that induced apoptosis in these cells (10 microM) produced a biphasic increase in [Ca2… CONTINUE READING

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