Activation of Xenopus eggs by RGD-containing peptides accompanied by intracellular Ca2+ release.

@article{Iwao1996ActivationOX,
  title={Activation of Xenopus eggs by RGD-containing peptides accompanied by intracellular Ca2+ release.},
  author={Yasuhiro Iwao and Takaji Fujimura},
  journal={Developmental biology},
  year={1996},
  volume={177 2},
  pages={558-67}
}
To investigate the mechanism of egg activation in Xenopus, unfertilized eggs were treated with various oligopeptides related to the RGD sequence-containing peptides. When dejellied eggs were treated with RGDS at concentrations higher than 250 microM, the eggs produced a positive-going activation potential concomitant with intracellular Ca2- release. The eggs underwent cortical granule breakdown, cortical contraction, and resumption of meiosis. The activation by RGDS was independent of the… CONTINUE READING

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