Activation of Ventrolateral Preoptic Neurons During Sleep

@article{Sherin1996ActivationOV,
  title={Activation of Ventrolateral Preoptic Neurons During Sleep},
  author={Jonathan E. Sherin and Priyattam J. Shiromani and Robert W. McCarley and Clifford B. Saper},
  journal={Science},
  year={1996},
  volume={271},
  pages={216 - 219}
}
The rostral hypothalamus and adjacent basal forebrain participate in the generation of sleep, but the neuronal circuitry involved in this process remains poorly characterized. Immunocytochemistry was used to identify the FOS protein, an immediate-early gene product, in a group of ventrolateral preoptic neurons that is specifically activated during sleep. The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral… 
View on AAAS
isites.harvard.edu
961 Citations
Highly Influential Citations
44
Background Citations
332
Methods Citations
37
Results Citations
19

961 Citations

Citation Type

Citation Type

Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species
Hypothalamic control of sleep.
Retinal input to the sleep-active ventrolateral preoptic nucleus in the rat
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.
TLDR
PGD2 increased nonrapid eye movement sleep and induced striking expression of Fos in the ventrolateral preoptic area (VLPO), a cluster of neurons that may promote sleep by inhibiting the tuberomammillary nucleus, the source of the ascending histaminergic arousal system.
Hypothalamic regulation of sleep and arousal.
TLDR
The hypothesis that non-REM sleep occurs as a consequence of GABAergic and galaninergic inhibition of arousal-promoting neurons resulting from activation of vlPOA and MnPN sleep-promoted neurons is suggested.
The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus
TLDR
The results indicate that the MnPN contains subset(s) of neurons, which exert inhibitory control over arousal-related and excitatory control over sleep-related PF/LH neurons, and hypothesize that MnPN sleep-active neuronal group has both inhibitory and excited outputs that participate in the inhibitory Control of arousal-promoting PF/ LH mechanisms.
Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons
GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons
TLDR
It is confirmed that specific pharmacogenetic stimulation of GABAergic neurons in the POA leads to an increase in the amount of non-rapid eye movement (NREM) sleep, and direct connectivity between POA GABAergic neuron and orexin neurons is examined.
Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion
Afferents to the Ventrolateral Preoptic Nucleus
TLDR
Robust pathways examined in afferents to the ventrolateral preoptic nucleus (VLPO) suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 72 REFERENCES
[Specific neurons for wakefulness in the posterior hypothalamus in the cat].
Using a single unit recording technique in freely moving Cats, we have demonstrated the presence of two groups of neurons in the ventrolateral part of the caudal hypothalamus. One is characterized by…
Enhancement of sleep by microinjection of triazolam into the medial preoptic area.
Sleep suppression following kainic acid-induced lesions of the basal forebrain
Firing properties of cat basal forebrain neurones during sleep-wakefulness cycle.
Sleep-waking discharge of neurons in the posterior lateral hypothalamic area of cats
A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats
Projections of GABAergic and cholinergic basal forebrain and GABAergic preoptic‐anterior hypothalamic neurons to the posterior lateral hypothalamus of the rat
Within the basal forebrain, γ‐aminobutyric acid (GABA)‐synthesizing neurons are codistributed with acetylcholine‐synthesizing neurons (Gritti et al. [1993] J. Comp. Neurol. 329:438–457), which…
Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats
Activity of preoptic neurons during synchronization and desynchronization
Effects of basal forebrain stimulation on the waking discharge of neurons in the midbrain reticular formation of cats
...
1
2
3
4
5
...