Activation of Ventrolateral Preoptic Neurons During Sleep

  title={Activation of Ventrolateral Preoptic Neurons During Sleep},
  author={Jonathan E. Sherin and Priyattam J. Shiromani and Robert W. McCarley and Clifford B. Saper},
  pages={216 - 219}
The rostral hypothalamus and adjacent basal forebrain participate in the generation of sleep, but the neuronal circuitry involved in this process remains poorly characterized. Immunocytochemistry was used to identify the FOS protein, an immediate-early gene product, in a group of ventrolateral preoptic neurons that is specifically activated during sleep. The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral… 

Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.

PGD2 increased nonrapid eye movement sleep and induced striking expression of Fos in the ventrolateral preoptic area (VLPO), a cluster of neurons that may promote sleep by inhibiting the tuberomammillary nucleus, the source of the ascending histaminergic arousal system.

Hypothalamic regulation of sleep and arousal.

The hypothesis that non-REM sleep occurs as a consequence of GABAergic and galaninergic inhibition of arousal-promoting neurons resulting from activation of vlPOA and MnPN sleep-promoted neurons is suggested.

The Median Preoptic Nucleus Reciprocally Modulates Activity of Arousal-Related and Sleep-Related Neurons in the Perifornical Lateral Hypothalamus

The results indicate that the MnPN contains subset(s) of neurons, which exert inhibitory control over arousal-related and excitatory control over sleep-related PF/LH neurons, and hypothesize that MnPN sleep-active neuronal group has both inhibitory and excited outputs that participate in the inhibitory Control of arousal-promoting PF/ LH mechanisms.

Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area

An excitatory brainstem-hypothalamic circuit that controls the wake-sleep transitions is uncovered, and it is shown that optogenetic activation of VLM glutamatergic neurons or their projections in the POA initiates NREM sleep in awake mice.

GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons

It is confirmed that specific pharmacogenetic stimulation of GABAergic neurons in the POA leads to an increase in the amount of non-rapid eye movement (NREM) sleep, and direct connectivity between POA GABAergic neuron and orexin neurons is examined.



[Specific neurons for wakefulness in the posterior hypothalamus in the cat].

Using a single unit recording technique in freely moving Cats, we have demonstrated the presence of two groups of neurons in the ventrolateral part of the caudal hypothalamus. One is characterized by

Enhancement of sleep by microinjection of triazolam into the medial preoptic area.

Firing properties of cat basal forebrain neurones during sleep-wakefulness cycle.

Projections of GABAergic and cholinergic basal forebrain and GABAergic preoptic‐anterior hypothalamic neurons to the posterior lateral hypothalamus of the rat

Within the basal forebrain, γ‐aminobutyric acid (GABA)‐synthesizing neurons are codistributed with acetylcholine‐synthesizing neurons (Gritti et al. [1993] J. Comp. Neurol. 329:438–457), which