Activation of V(D)J recombination at the IgH chain JH locus occurs within a 6-kilobase chromatin domain and is associated with nucleosomal remodeling.

@article{Mas2006ActivationOV,
  title={Activation of V(D)J recombination at the IgH chain JH locus occurs within a 6-kilobase chromatin domain and is associated with nucleosomal remodeling.},
  author={J{\'e}r{\^o}me Ma{\"e}s and Stephane Chappaz and Patricia Cavelier and Laura O'Neill and Bryan M. Turner and François Rougeon and Mich{\`e}le Goodhardt},
  journal={Journal of immunology},
  year={2006},
  volume={176 9},
  pages={5409-17}
}
IgH genes are assembled during early B cell development by a series of regulated DNA recombination reactions in which DH and JH segments are first joined followed by V(H) to DJH rearrangement. Recent studies have highlighted the role of chromatin structure in the control of V(D)J recombination. In this study, we show that, in murine pro-B cell precursors, the JH segments are located within a 6-kb DNase I-sensitive chromatin domain containing acetylated histones H3 and H4, which is delimited 5… CONTINUE READING

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